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Our History of Innovation in Cancer Care

At BeOne Medicines we are relentlessly innovating to accelerate the development and delivery of transformative medicines for cancer that are accessible to more people with cancer around the world. With three approved medicines across global markets and more than 30 investigational medicines in development, we are how the world fights cancer.

Scientists collaborate around a microscope, discussing cancer therapy treatment advancements.
2010

A Vision is Born

Founders John V. Oyler and Xiaodong Wang launch a global company with a bold mission: to transform cancer treatment through innovation—making breakthrough medicines not only effective, but also accessible for patients around the world.

Two BeOne Medicines company leaders
2011

Merck KGaA, Darmstadt, Germany provided early backing of $20 million as part of the first external investment in the Company.

The Doors to Discovery Open

A new era of cancer research begins: the Company opens its first R&D center, zeroing in on PARP and RAF pathways.

Scientists conducting pharmaceutical research in a laboratory
2012

Merck KGaA, Darmstadt, Germany supported the Company’s early pipeline, biomarker research, and preclinical R&D.

Scientist conducting pharmaceutical research in a laboratory

From Molecules to Milestones

Discovery programs targeting PD-1 and BTK begin. Out of more than 500 compounds, one molecule stands out—BGB-3111, a BTK inhibitor, becomes the 3,111th compound synthesized in just two years. It marks the start of a future breakthrough.

2013-2015

Pushing Boundaries

The Company’s experimental compounds—lifirafenib (RAF), pamiparib (PARP), and zanubrutinib (BTK)—enter clinical development in Australia.

World map showing BeOne Medicines global operations

Expansion in the U.S.

The Company expands its U.S. roots to Massachusetts.

Boston skyline
2016

Goes Public on Nasdaq

The Company debuts on the Nasdaq, fueling the next stage of growth and innovation in oncology.

Nasdaq listing logo

The Company announces first patient dosing for investigational BTK Inhibitor BGB-3111.

Patient and healthcare professional during a clinical consultation
2017

First European Office

A new European office opens in Switzerland – positioning the Company at the heart of a key hub of the global pharmaceutical and biotech ecosystem.

Tram traveling through a Swiss city street

Continued Partnerships

Celgene licensed global (ex-Asia) rights to the Company’s anti-PD-1 antibody tislelizumab.

2018

Global Momentum

The Company is listed on the Hong Kong Stock Exchange (HKEX) with a stock code of 06160, raising over $900 million.

Hong Kong Stock Exchange (HKEX) listing logo
2019

First FDA Approval

BRUKINSA® (zanubrutinib) is approved by the U.S. FDA, becoming the Company’s first approved medicine—just seven years after discovery.

Read About the Approval

The Company regained full global rights to tislelizumab.

TEVIMBRA® (tislelizumab) Approval in China

Read About the Approval
2020

Building Global Strength

Amgen and the Company entered into a strategic collaboration with a $2.7 billion equity investment from Amgen.

Amgen logo

Clinical operations begin to move in house, setting the stage for trial efficiency at scale.

Strength in Numbers

The Company surpasses 5,000 global employees.

BeOne Medicines' global workforce of 5,000+ employees

Pamiparib Approval in China

Learn More About the Approval
2021

Innovation Without Borders

Listed on the Shanghai Stock Exchange (SSE) STAR Market (Science and Technology Innovation Board of Shanghai Stock Exchange) with a stock code of 688235 on December 15, 2021. The listing made the Company the first biotech in the world to be listed simultaneously on Nasdaq, HKEX, and the Shanghai STAR Market.

Shanghai Stock Exchange (SSE) logo

Doubling Down on Innovation

The Company opens the Guangzhou Bioisland Innovation Center, a cutting-edge research hub exploring novel cancer pathways to address unmet needs worldwide.

Modern cancer research facility focused on pioneering cancer therapy treatments and advancing methods for treating cancer.

Novartis and the Company entered a strategic collaboration and license agreement for tislelizumab, the Company’s anti-PD-1 antibody.

Novartis logo

The European Commission (EC) granted the first marketing approval of Brukinsa in the EU on November 23, 2021.

2022

A Year of Impact

Officially broke ground on its flagship U.S. biologics manufacturing and clinical R&D facility at the Princeton West Innovation Campus in Hopewell, New Jersey that would become a 400,000 sq ft center—part of a 42-acre site designed to include commercial-scale biologic manufacturing and clinical R&D development space.

BeOne Medicines research and development campus

U.S. Revenue Climbs, Driving Strong Financial Results

Company surpasses $1 billion in revenue, a testament to growing global influence.

Bringing Hope to People with CLL

Alpine Phase 3 trial results show our BTK inhibitor demonstrated superior progression-free survival in relapsed or refractory CLL compared to ibrutinib-a major leap forward in treatment outcomes.

Scientist analyzing genomic and biomedical research data
2023

Deepening Global Reach

TEVIMBRA® gains European approval; global rights regained from Novartis.

Invests in a state-of-the-art manufacturing facility in Suzhou, capable of producing 600 million oral doses annually.

State-of-the-art facility in Suzhou, dedicated to breakthroughs in cancer therapy treatment and advancing cancer care.

Launch of the BeOne Care Foundation, breaking down barriers to accessible cancer care.

Novartis and the Company agreed to fully return global rights to tislelizumab to the Company so it could develop, manufacture, and commercialize TEVIMBRA.

Delivering on Our Vision to Expand Access

In partnership with The Max Foundation and the BeOne Care Foundation, the Company begins providing access to its CLL treatment to low- and middle-income countries.

Launch of Global Employee Volunteer Program

Achieved 10,000 volunteer hours worldwide

2024

A Landmark Year

TEVIMBRA® receives FDA approval, becoming the cornerstone of the Company’s solid tumor portfolio.

Read about the approval

Changing Lives Around the World

One million patients worldwide have now been treated with the Company’s medicines.

Opens the flagship U.S. biologics facility, a 400,000 sq ft center—part of a 42-acre site, in Hopewell, NJ, driving speed, efficiency, and excellence.

2025

A Year of Transformation

Changes stock ticker to ONC reinforcing global focus and commitment to oncology.

Nasdaq-listed company badge

Company reaches ~12,000 employees across six continents— living its mission on a truly global scale.

Global workforce map showing 12,000 BeOne Medicines employees across six continents

75+ countries with regulatory approval across three internally developed medicines reaching over 1.8 million patients.

BeOne Medicines' global reach across 75+ countries and 1.8 million patients

Consolidation of California offices to the Bay Area to accommodate growing team and lab space needs.

New Name, Same Mission

Announced name change to BeOne Medicines and redomiciliation to Basel, Switzerland.

BeOne Medicines logo
2026

Expanding Access to the Treatment of CLL in Underserved Markets

The Company renews its partnership with the BeOne Care Foundation and The Max Foundation, building on access provided to more than 300 patients with CLL and planning to support approximately 1,000 patients through 2028.

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